Chapter 3. Airway Smooth Muscle: Role in Airway Constrictor Hyperresponsiveness

  1. Kian Fan Chung
  1. Melanie Brown1 and
  2. Julian Solway Professor1,2

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch3

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Brown, M. and Solway, J. (2008) Airway Smooth Muscle: Role in Airway Constrictor Hyperresponsiveness, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch3

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. 1

    Section of Critical Care, Department of Pediatrics, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA

  2. 2

    Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • airway constrictor hyperresponsiveness (AHR);
  • asthma airflow obstruction;
  • lung embryology and AHR;
  • early-phase and late-phase airflow obstruction;
  • airway wall fibrosis - fixed airway obstruction;
  • airway surfactant influencing airway function;
  • ASM potential abnormalities;
  • ASM - CF, sudden infant death syndrome (SIDS), and asthma

Summary

This chapter contains sections titled:

  • What is airway constrictor hyperresponsiveness (AHR)?

  • Is AHR ever good?

  • Potential mechanisms leading to airflow obstruction

  • Potential abnormalities of airway smooth muscle (ASM)

  • If ASM is dysfunctional, how did it get that way?

  • Summary

  • Acknowledgements

  • References