Chapter 4. Airway Smooth Muscle Phenotypic and Functional Plasticity

  1. Kian Fan Chung
  1. Andrew J. Halayko Associate Professor Canada Research Chair1,2,3,
  2. Reinoud Gosens2,3,† and
  3. Thai Tran2,3,‡

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch4

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Halayko, A. J., Gosens, R. and Tran, T. (2008) Airway Smooth Muscle Phenotypic and Functional Plasticity, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch4

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. 1

    Section of Respiratory Disease, Health Sciences Centre, RS321 – 810 Sherbrook Street, Winnipeg, MB, Canada R3A 1R8

  2. 2

    Departments of Physiology and Internal Medicine, Section of Respiratory Disease, and National Training Program in Allergy and Asthma, University of Manitoba, Winnipeg, MB, Canada

  3. 3

    Biology of Breathing Theme, Manitoba Institute of Child Health, Winnipeg, MB, Canada

  1. Department of Molecular Pharmacology, University of Groningen, The Netherlands

  2. Department of Physiology, National University of Singapore, Singapore

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • airway smooth muscle (ASM) phenotypic and functional plasticity;
  • smooth muscle phenotype plasticity;
  • contractile smooth muscle cells and spontaneous phenotype modulation;
  • phenotypic plasticity mechanisms;
  • airway smooth muscle phenotype maturation mechanism;
  • asthma pathogenesis - phenotypic and functional plasticity;
  • asthma and cellular hyperplasia and hypertrophy;
  • airway smooth muscle dynamic functional behaviour

Summary

This chapter contains sections titled:

  • Introduction

  • Historical perspective: smooth muscle phenotype plasticity

  • Features of phenotype plasticity

  • Mechanisms for phenotypic plasticity

  • Functional plasticity of airway smooth muscle: role in asthma pathogenesis

  • Concluding remarks

  • References