Chapter 5. Airway Smooth Muscle Proliferation: Insights into Mechanisms Regulating Airway Smooth Muscle Mass

  1. Kian Fan Chung
  1. Reynold A. Panettieri Jr.

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch5

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Panettieri, R. A. (2008) Airway Smooth Muscle Proliferation: Insights into Mechanisms Regulating Airway Smooth Muscle Mass, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch5

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. Pulmonary, Allergy & Critical Care Division, University of Pennsylvania School of Medicine, Airways Biology Initiative, 125 South 31st Street, TRL Suite 1200, Philadelphia, PA 19104-3403, USA

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • airway smooth muscle (ASM) mass and fatal asthma;
  • ASM proliferation - ASM mass and asthma severity;
  • ASM functional consequences and airway myocytes in vitro;
  • bronchoalveolar lavage (BAL) inflammatory mediator;
  • ASM cell mitogenesis and RTK activity;
  • extracellular signal-regulated kinase (ERK) pathway;
  • PI3K inhibition and ERK activation;
  • cAMP response element-binding protein (CREB) phosphorylation

Summary

This chapter contains sections titled:

  • Increases in airway smooth muscle (ASM) mass and the functional consequences

  • Growth factors, inflammatory mediators and cytokines modulate ASM proliferation

  • References