Chapter 6. Airway Smooth Muscle Bidirectional Interactions with Extracellular Matrix

  1. Kian Fan Chung
  1. Jane E. Ward Lecturer1 and
  2. Stuart J. Hirst Reader2

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch6

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Ward, J. E. and Hirst, S. J. (2008) Airway Smooth Muscle Bidirectional Interactions with Extracellular Matrix, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch6

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. 1

    Department of Pharmacology, Faculty of Medicine, Dentistry and Health Sciences, Level 8, Medical Building, Corner of Grattan Street and Royal Parade, University of Melbourne, Victoria 3010, Australia

  2. 2

    MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy & Lung Biology, The Guy's, King's College & St. Thomas' School of Medicine, King's College London, 5th Floor, Thomas Guy House, Guy's Hospital Campus, London SE1 9RT, UK

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • fibrotic response and extracellular matrix (ECM) tissue;
  • airway smooth muscle (ASM) bidirectional interactions;
  • lung tissue remodelling and persistent inflammation;
  • ECM and matrix metalloproteinases (MMPs);
  • ECM protein integrins;
  • ASM as airway ECM modulator;
  • epidermal growth factor (EGF) effect on ECM synthesis;
  • ECM signal and cultured ASM cells;
  • ASM and anti-asthma agents

Summary

This chapter contains sections titled:

  • Overview

  • Introduction

  • Airway extracellular matrix (ECM) in health and disease

  • Integrins

  • Airway smooth muscle (ASM) as a modulator of airway ECM

  • Airway ECM as modulator of ASM function

  • Impact of anti-asthma therapy on ASM–ECM interactions

  • Conclusions

  • Acknowledgements

  • References