Chapter 9. Airway Smooth Muscle in Experimental Models

  1. Kian Fan Chung
  1. Anne-Marie Lauzon and
  2. James G. Martin

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch9

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Lauzon, A.-M. and Martin, J. G. (2008) Airway Smooth Muscle in Experimental Models, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch9

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain Street, Montréal, Québec, Canada, H2X 2P2

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • ASM and airway hyperresponsiveness (AHR);
  • ASM function – assessment in vivo;
  • experimental model airway smooth muscle (ASM);
  • smooth muscle myosin heavy chain (SMMHC) isoform;
  • airway responsiveness and allergen challenge;
  • allergen induced AHR in ASM;
  • airway luminal decrease via ASM contraction;
  • animal and in vitro model bronchoconstriction tools

Summary

This chapter contains sections titled:

  • Introduction

  • Methods of assessment of airway smooth muscle (ASM) function

  • Potential mechanisms by which ASM properties may contribute to airway responsiveness

  • Experimental models

  • Conclusion

  • Acknowledgement

  • References