Chapter 23. The Role of the Neutrophil in the Pathogenesis of COPD

  1. Robert A. Stockley Professor1,
  2. Stephen I. Rennard Professor2,
  3. Klaus Rabe Professor3 and
  4. Bartolome Celli Professor4
  1. Ian S. Woolhouse and
  2. Robert A. Stockley

Published Online: 11 JAN 2008

DOI: 10.1002/9780470755976.ch23

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

How to Cite

Stockley, R. A., Rennard, S. I., Rabe, K. and Celli, B. (2007) The Role of the Neutrophil in the Pathogenesis of COPD, in Chronic Obstructive Pulmonary Disease, Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470755976.ch23

Author Information

  1. 1

    Professor of Medicine, Department of Medicine, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

  2. 2

    Pulmonary & Critical Care Medicine Section, University of Nebraska Medical Center, 985125 Nebraska Medical Center, 800 South 42nd Street, Omaha, NE 68198-5300

  3. 3

    Dept of Pulmonology, Leiden Universtiy Medical Centre, Albinusdreef 2, C3-P, Postbox 9600, 2300 RC, Leiden, Netherlands

  4. 4

    Division of Pulmonary and Critical Care, St Elizabeth's Medical Centre, 736 Cambridge Street, Tufts University, Boston, MA 02135-2907

Publication History

  1. Published Online: 11 JAN 2008
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122894

Online ISBN: 9780470755976

SEARCH

Keywords:

  • pluripotential stem cells;
  • animal models;
  • neutrophil differentiation;
  • blood leucocyte;
  • neutrophil recruitment

Summary

This chapter contains sections titled:

  • Evidence for the role of the neutrophil in the pathogenesis of COPD

  • Neutrophil differentiation and maturation

  • Neutrophil recruitment to the lungs

  • Neutrophil effector function in COPD

  • The neutrophil as a target for anti-inflammatory therapy

  • Conclusions

  • References