Chapter 27. Cigarette Smoking, Emphysema and Lung Endothelium

  1. Robert A. Stockley Professor1,
  2. Stephen I. Rennard Professor2,
  3. Klaus Rabe Professor3 and
  4. Bartolome Celli Professor4
  1. Stephanie A. Nonas,
  2. Irina Petrache and
  3. Joe G. N. Garcia

Published Online: 11 JAN 2008

DOI: 10.1002/9780470755976.ch27

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

How to Cite

Stockley, R. A., Rennard, S. I., Rabe, K. and Celli, B. (2007) Cigarette Smoking, Emphysema and Lung Endothelium, in Chronic Obstructive Pulmonary Disease, Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470755976.ch27

Author Information

  1. 1

    Professor of Medicine, Department of Medicine, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

  2. 2

    Pulmonary & Critical Care Medicine Section, University of Nebraska Medical Center, 985125 Nebraska Medical Center, 800 South 42nd Street, Omaha, NE 68198-5300

  3. 3

    Dept of Pulmonology, Leiden Universtiy Medical Centre, Albinusdreef 2, C3-P, Postbox 9600, 2300 RC, Leiden, Netherlands

  4. 4

    Division of Pulmonary and Critical Care, St Elizabeth's Medical Centre, 736 Cambridge Street, Tufts University, Boston, MA 02135-2907

Publication History

  1. Published Online: 11 JAN 2008
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122894

Online ISBN: 9780470755976



  • pulmonary emphysema;
  • lung homeostasis;
  • endothelial cells;
  • oxidative stress;
  • matrix proteolysis


This chapter contains sections titled:

  • Endothelial cell barrier function in lung inflammation

  • Endothelial cell paracrine and cell survival function in lung homeostasis

  • Endothelial cells in emphysema development: a historical perspective

  • Endothelium in airspace enlargement: role of endothelial growth factors

  • Cigarette smoke and the role of oxidative stress in endothelial dysfunction and emphysema development

  • Conclusions

  • References