Chapter 68. Protease Inhibitors

  1. Robert A. Stockley Professor1,
  2. Stephen I. Rennard Professor2,
  3. Klaus Rabe Professor3 and
  4. Bartolome Celli Professor4
  1. Philip Davies,
  2. Malcolm MacCoss and
  3. Richard Mumford

Published Online: 11 JAN 2008

DOI: 10.1002/9780470755976.ch68

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

How to Cite

Stockley, R. A., Rennard, S. I., Rabe, K. and Celli, B. (2007) Protease Inhibitors, in Chronic Obstructive Pulmonary Disease, Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470755976.ch68

Author Information

  1. 1

    Professor of Medicine, Department of Medicine, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

  2. 2

    Pulmonary & Critical Care Medicine Section, University of Nebraska Medical Center, 985125 Nebraska Medical Center, 800 South 42nd Street, Omaha, NE 68198-5300

  3. 3

    Dept of Pulmonology, Leiden Universtiy Medical Centre, Albinusdreef 2, C3-P, Postbox 9600, 2300 RC, Leiden, Netherlands

  4. 4

    Division of Pulmonary and Critical Care, St Elizabeth's Medical Centre, 736 Cambridge Street, Tufts University, Boston, MA 02135-2907

Publication History

  1. Published Online: 11 JAN 2008
  2. Published Print: 1 JAN 2007

ISBN Information

Print ISBN: 9781405122894

Online ISBN: 9780470755976

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Keywords:

  • protease activity;
  • hypothesis;
  • functional pathology;
  • pharmacological inhibition;
  • antibodies

Summary

This chapter contains sections titled:

  • Proteases with potential for involvement in inflammation and tissue damage leading to functional pathology in COPD

  • Innate immune responses, inflammation and tissue damage in COPD

  • Elucidation of the role of proteases in COPD

  • The development of protease inhibitors as drugs for chronic in flammatory diseases

  • Conclusions

  • Acknowledgements

  • References