4. Biodistribution and Pharmacokinetics of Nanoprobes

  1. Xiaoyuan Chen4,5
  1. Nagesh Kolishetti1,
  2. Frank Alexis2,
  3. Eric M. Pridgen3 and
  4. Omid C. Farokhzad1

Published Online: 25 MAY 2011

DOI: 10.1002/9780470767047.ch4

Nanoplatform-Based Molecular Imaging

Nanoplatform-Based Molecular Imaging

How to Cite

Kolishetti, N., Alexis, F., Pridgen, E. M. and Farokhzad, O. C. (2011) Biodistribution and Pharmacokinetics of Nanoprobes, in Nanoplatform-Based Molecular Imaging (ed X. Chen), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470767047.ch4

Editor Information

  1. 4

    Molecular Imaging Program at Stanford and Bio-X Program, Department of Radiology, Stanford University School of Medicine, Stanford, California, USA

  2. 5

    Laboratory for Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA

Author Information

  1. 1

    Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

  2. 2

    Department of Bioengineering, Clemson University, Clemson, South Carolina, USA

  3. 3

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 25 MAY 2011
  2. Published Print: 28 MAR 2011

ISBN Information

Print ISBN: 9780470521151

Online ISBN: 9780470767047



  • nanoprobe biodistribution and pharmacokinetics - nanoprobe toxicity, in biomedical and clinical applications;
  • nanoparticle-based technology - factors affecting nanoprobe biodistribution and pharmacokinetics, as size, shape, surface functionality/coating and charge;
  • theragnostic nanoprobes, and nanoparticle delivery systems - therapeutic vehicle with multiple examples approved by FDA for therapy


This chapter contains sections titled:

  • Introduction

  • Nanoprobe Technologies

  • Nanoprobe Toxicity

  • Nanoprobe Clinical Translation

  • Factors Affecting the Biodistribution and Pharmacokinetics

  • Theragnostic Nanoprobes

  • Conclusion

  • Acknowledgement

  • References