13. Practical Issues

  1. Stephen J. Walters

Published Online: 10 SEP 2009

DOI: 10.1002/9780470840481.ch13

Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation

Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation

How to Cite

Walters, S. J. (2009) Practical Issues, in Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470840481.ch13

Author Information

  1. School of Health and Related Research, University of Sheffield, UK

Publication History

  1. Published Online: 10 SEP 2009
  2. Published Print: 25 SEP 2009

ISBN Information

Print ISBN: 9780470753828

Online ISBN: 9780470686140

SEARCH

Keywords:

  • practical issues in analysing studies using QoL outcomes;
  • US Food and Drug Administration (FDA) draft guidance for using QoL outcomes;
  • missing data proportion and its importance;
  • missing forms - more serious than missing items;
  • last observation carried forward (LOCF);
  • regression imputation of missing forms;
  • PONDER study - cluster randomized controlled trial (cRCT) in primary care;
  • EPDS, Edinburgh Postnatal Depression Scale;
  • simpler univariate approach and each individual QoL dimension;
  • quality of life outcome measures in clinical trials

Summary

This chapter contains sections titled:

  • Summary

  • Missing data

  • Multiplicity, multi-dimensionality and multiple quality of life outcomes

  • Guidelines for reporting quality of life studies