8. Randomized Controlled Trials
Published Online: 10 SEP 2009
DOI: 10.1002/9780470840481.ch8
Copyright © 2009 John Wiley & Sons, Ltd
Book Title
Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation
Additional Information
How to Cite
Walters, S. J. (2009) Randomized Controlled Trials, in Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470840481.ch8
Publication History
- Published Online: 10 SEP 2009
- Published Print: 25 SEP 2009
Book Series:
ISBN Information
Print ISBN: 9780470753828
Online ISBN: 9780470686140
- Summary
- Chapter
Keywords:
- randomized controlled trials (RCTs) in evaluating alternative treatments or interventions;
- randomized double-blind and writing study protocol;
- Consolidation of Standards for Reporting Trials (CONSORT) statement;
- intention-to-treat and per-protocol analyses;
- patient flow diagram;
- CONSORT statement and reporting results of RCTs;
- CONSORT flow chart for acupuncture study;
- minimum clinically important difference (MCID);
- cluster randomized controlled trials
Summary
This chapter contains sections titled:
Summary
Introduction
Randomized controlled trials
Protocols
Pragmatic and explanatory trials
Intention-to-treat and per-protocol analyses
Patient flow diagram
Comparison of entry characteristics
Incomplete data
Main analysis
Interpretation of changes/differences in quality of life scores
Superiority and equivalence trials
Adjusting for other variables
Three methods of analysis for pre-test/post-test control group designs
Cross-over trials
Factorial trials
Cluster randomized controlled trials
Further reading