Chapter 4. Methods in Toxicology

  1. Helmut Greim M.D.9 and
  2. Robert Snyder Ph.D. Associate Dean for Research Professor of Pharmacology and Toxicology10
  1. Rüdiger Bartsch9,
  2. Ilse-Dore Adler1,
  3. Ulrich Andrae2,
  4. Günter Speit3,
  5. Stephan Madle4,
  6. Peter Kasper5,
  7. Ulrike Pabel4,
  8. Michael G. Bird6,
  9. Kurt Ulm7,
  10. Laura Suter-Dick8,
  11. Thomas Singer8 and
  12. György Csanády2

Published Online: 8 FEB 2008

DOI: 10.1002/9780470868959.ch4

Toxicology and Risk Assessment: A Comprehensive Introduction

Toxicology and Risk Assessment: A Comprehensive Introduction

How to Cite

Bartsch, R., Adler, I.-D., Andrae, U., Speit, G., Madle, S., Kasper, P., Pabel, U., Bird, M. G., Ulm, K., Suter-Dick, L., Singer, T. and Csanády, G. (2008) Methods in Toxicology, in Toxicology and Risk Assessment: A Comprehensive Introduction (eds H. Greim and R. Snyder), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470868959.ch4

Editor Information

  1. 9

    Institut für Toxikologie und Umwelthygiene, Technische Universität München, Germany

  2. 10

    Ernest Mario School of Pharmacy and the Environmental and Occupational Health Sciences Institute, Rutgers the State University of New Jersey, Piscataway, USA

Author Information

  1. 1

    Institut für Genetik, GSF-Forschungszentrum für Umwelt & Gesundheit, Neuherberg, Germany

  2. 2

    Institut für Toxikologie, GSF-Forschungszentrum für Umwelt & Gesundheit, Neuherberg, Germany

  3. 3

    Institut für Humangenetik, Universität Ulm, Germany

  4. 4

    Bundesinstitut für Risikobewertung, Berlin, Germany

  5. 5

    Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany

  6. 6

    Toxicology & Environmental Sciences Division, ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey, USA

  7. 7

    Institut für Medizinische Statistik und Epidemiologie des Klinikums Rechts der Isar der Technischen Universität München, Germany

  8. 8

    F. Hoffmann-La Roche AG, Basel, Switzerland

  9. 9

    Institut für Toxikologie und Umwelthygiene, Technische Universität München, Germany

Publication History

  1. Published Online: 8 FEB 2008
  2. Published Print: 25 JAN 2008

ISBN Information

Print ISBN: 9780470868935

Online ISBN: 9780470868959

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Keywords:

  • mechanistically plausible expectation;
  • maximum tolerated dose (MTD);
  • xenobiotic-metabolizing enzymes;
  • organ-specific genotoxic events;
  • mouse fibroblast cell lines;
  • mammalian cell mutagenicity tests;
  • time– and dose–effect relationship;
  • corresponding mortality rate;
  • gene- and protein-expression measurements;
  • common unimodal distribution

Summary

This chapter contains sections titled:

  • OECD Test Guidelines for Toxicity Tests in vivo

  • Mutagenicity Tests in vivo

  • In vitro Tests for Genotoxicity

  • Strategies for the Evaluation of Genotoxicity

  • Biomonitoring

  • Epidemiology

  • Omics in Toxicology

  • Introduction to the Statistical Analysis of Experimental Data

  • References

  • For Further Reading

  • Further Reading