8. Characterization of Conformational Patterns in Active and Inactive Forms of Kinases Using Protein Blocks Approach

  1. Ujjwal Maulik3,
  2. Sanghamitra Bandyopadhyay4 and
  3. Jason T. L. Wang5
  1. G. Agarwal1,
  2. D. C. Dinesh1,
  3. N. Srinivasan1 and
  4. Alexandre G. de Brevern2

Published Online: 25 AUG 2010

DOI: 10.1002/9780470872352.ch8

Computational Intelligence and Pattern Analysis in Biological Informatics

Computational Intelligence and Pattern Analysis in Biological Informatics

How to Cite

Agarwal, G., Dinesh, D. C., Srinivasan, N. and de Brevern, A. G. (2010) Characterization of Conformational Patterns in Active and Inactive Forms of Kinases Using Protein Blocks Approach, in Computational Intelligence and Pattern Analysis in Biological Informatics (eds U. Maulik, S. Bandyopadhyay and J. T. L. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470872352.ch8

Editor Information

  1. 3

    Department of Computer Science and Engineering, Jadavpur University, Kolkata, India

  2. 4

    Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India

  3. 5

    Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, USA

Author Information

  1. 1

    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

  2. 2

    Université Paris Diderot-Paris, Institut National de Transfusion Sanguine (INTS), Paris, France

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470581599

Online ISBN: 9780470872352

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Keywords:

  • characterization of conformational patterns in active and inactive forms of kinases using protein blocks approach;
  • three-dimensional (3D) structure, critical for function of protein - conserved during evolution;
  • distinguishing conformational variations - from rigid-body shifts

Summary

This chapter contains sections titled:

  • Introduction

  • Distinguishing Conformational Variations from Rigid-Body Shifts in Active and Inactive Forms of a Kinase

  • Cross Comparison of Active and Inactive forms of Closely Related Kinases

  • Comparison of the Active States of Homologous Kinases

  • Conclusions

  • Acknowledgments

  • References