Chapter 11. Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for Predicting Uptake and Localization of Nanoparticles in Living Cells? And If Not, Why Not?

  1. Volkmar Weissig2 and
  2. Gerard G. M. D'Souza3
  1. Richard W. Horobin

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch11

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Horobin, R. W. (2010) Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for Predicting Uptake and Localization of Nanoparticles in Living Cells? And If Not, Why Not?, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch11

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 3

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. Division of Integrated Biology, FBLS, The University of Glasgow, Glasgow, Scotland, United Kingdom

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780

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Keywords:

  • QSAR models describing small-molecule xenobiotics - predicting uptake and localization of nanoparticles in living cells;
  • QSAR decision rule models - predicting occurrence or nonoccurrence of processes;
  • small-molecule QSAR models and nanoparticle uptake and localization

Summary

This chapter contains sections titled:

  • Questions and their Context

  • Some Background: The Meaning of “Nanoparticles”

  • Predicting Uptake and Localization of Small - Molecule Xenobiotics using QSAR Models

  • More Background: What Factors Control Uptake and Intracellular Localization of Nanoparticles?

  • So can Small - Molecule QSAR Models tell us Anything about Nanoparticle Uptake and Localization?

  • Simple Numerical Summaries of Nanoparticle Uptake and Intracellular Localization

  • Acknowledgment

  • References