Chapter 13. Cellular Trafficking of Dendrimers

  1. Volkmar Weissig2 and
  2. Gerard G. M. D'Souza3
  1. Yunus Emre Kurtoglu and
  2. Rangaramanujam M. Kannan

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch13

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Kurtoglu, Y. E. and Kannan, R. M. (2010) Cellular Trafficking of Dendrimers, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch13

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 3

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. Department of Chemical Engineering and Materials Science, NICHD Perinatology Research Branch, Wayne State University, Detroit, Michigan, USA

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780



  • cellular trafficking of dendrimers;
  • dendritic versus linear and hyperbranched polymers;
  • oral delivery of dendrimer drug conjugates - importance of epithelial barrier permeability evaluation


This chapter contains sections titled:

  • Dendritic Architecture

  • Dendritic Versus Linear and Hyperbranched Polymers

  • Surface Charge

  • Surface Modification

  • Permeability through Biological Barriers

  • siRNA Oligonucleotide Delivery

  • Intracellular Trafficking and Efficacy

  • Key Aspects in Data Interpretation

  • Conclusion

  • References