Chapter 15. Uptake and Intracellular Dynamics of Proteins Internalized by Cell-Penetrating Peptides

  1. Volkmar Weissig2 and
  2. Gerard G. M. D'Souza3
  1. Arwyn T. Jones

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch15

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Jones, A. T. (2010) Uptake and Intracellular Dynamics of Proteins Internalized by Cell-Penetrating Peptides, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch15

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 3

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. Welsh School of Pharmacy, Cardiff University, Cardiff, Wales, United Kingdom

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780



  • uptake and intracellular dynamics of proteins internalized by cell-penetrating peptides;
  • GFP variants, delivered to cells - extending sequence with octaarginie (R8), HIV-Tat;
  • systems for attaching cell-penetrating peptides to proteins


This chapter contains sections titled:

  • Introduction

  • Endocytic Pathways

  • Delivering Proteins into Cells

  • HIV-Tat Protein

  • Protein Delivery by Octaarginine

  • Systems for Attaching Cell-Penetrating Peptides to Proteins

  • Targeting Lysosomes

  • Comparing CPP Fusion Proteins with CPP Fluorophores

  • Conclusion

  • Acknowledgments

  • References