Chapter 19. Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro- and Nanoscale Particles

  1. Volkmar Weissig2 and
  2. Gerard G. M. D'Souza3
  1. Galya Orr

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch19

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Orr, G. (2010) Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro- and Nanoscale Particles, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch19

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 3

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. Chemical and Materials Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780



  • organelle-specific pharmaceutical nanotechnology - active cellular transport of submicro- and nanoscale particles;
  • transport systems - dynamic cytoskeletal filaments and associated motor proteins;
  • heparan sulfate proteoglycans - critical role in attachment and internalization of positively charged inorganic particles


This chapter contains sections titled:

  • Viruses Inspire the Design of Synthetic Carriers

  • Motor Proteins Power the Transport of Viruses and Synthetic Particles along Cytoskeletal Filaments

  • Active Transport within and between Cells can be Powered by Actin Polymerization

  • Actin Flow Underlies the Surfing of Viruses Along Filopodia or Microvilli Toward the Cell Body

  • Submicro - and Nanoscale Inorganic Particles can be Propelled along Filopodia and Microvilli

  • Retrograde Motion is Mediated by Transmembrane Molecules that Interact Directly or Indirectly with Actin Filaments

  • Heparan Sulfate Proteoglycans Play a Critical Role in the Attachment and Internalization of Positively Charged Inorganic Particles

  • Syndecan - 1 mediates the Coupling of Positively Charged Inorganic Particles with Actin Filaments Across the Cell Membrane

  • Positively Charged Inorganic Particles can Induce Syndecan - 1 Clustering and Subsequent Actin Coupling and Internalization

  • Conclusion

  • Acknowledgment

  • References