Chapter 23. Therapeutic Nano-Object Delivery to Subdomains of Cardiac Myocytes

  1. Volkmar Weissig3 and
  2. Gerard G. M. D'Souza4
  1. Valeriy Lukyanenko1,2

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch23

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Lukyanenko, V. (2010) Therapeutic Nano-Object Delivery to Subdomains of Cardiac Myocytes, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch23

Editor Information

  1. 3

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 4

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. 1

    Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA

  2. 2

    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780



  • therapeutic nano-object delivery - to cardiac myocyte subdomains;
  • successful nano-object delivery - nano-objects penetrating vascular wall;
  • transmembrane pathways for nano-object internalization


This chapter contains sections titled:

  • Introduction

  • Structure of Ventricular Cell

  • Nano - Objects and their Analytical Applications

  • Cardiac Vascular Permeability

  • Transmembrane Pathways for Internalization of Nano-Objects

  • Intracellular Barriers for Nano - Objects

  • Changes in Ventricular Cell Ultrastructure Associated with Heart Failure

  • Methods for Studying the Delivery of Nano - Objects to Intracellular Subdomains of Cardiac Myocytes

  • Confirmed Deliveries of Nano - Object to Cardiomyocytes in Vivo

  • Conclusion

  • References