Chapter 24. Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents

  1. Volkmar Weissig3 and
  2. Gerard G. M. D'Souza4
  1. Silvia Muro1 and
  2. Vladimir R. Muzykantov2

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch24

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Muro, S. and Muzykantov, V. R. (2010) Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch24

Editor Information

  1. 3

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 4

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. 1

    Center for Biosystems Research, University of Maryland Biotechnology Institute and Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA

  2. 2

    Department of Pharmacology and Targeted Therapeutics Program of Institute of Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780

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Keywords:

  • design parameters modulating intracellular drug delivery - anchoring to specific cellular epitopes, carrier geometry and auxiliary pharmacological agent use;
  • intracellular drug delivery via CAM endocytosis - antioxidant and lysosome replacement enzymes;
  • subcellular destination of drug delivery in selected target cells - the Holy Grail of modern biomedicine

Summary

This chapter contains sections titled:

  • Introduction: Intracellular Delivery of Drug Carriers

  • Vesicular Endocytic Pathways: Natural Gateways for Intracellular Transport and Delivery Of Drugs

  • CAM - Mediated Endocytosis: An Inducible Pathway for Intracellular Delivery of a Wide Range of Drug Carriers

  • Examples of Intracellular Drug Delivery Via CAM Endocytosis: Antioxidant and Lysosome Replacement Enzymes

  • Optimization of Intracellular Drug Delivery Via CAM - Mediated Endocytosis using Pharmacological agents, Selection of the Epitope, and Carrier Geometry

  • Conclusion

  • Acknowledgments

  • References