Chapter 5. Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and Therapeutic Agents

  1. Volkmar Weissig2 and
  2. Gerard G. M. D'Souza3
  1. Neil Bricklebank

Published Online: 25 AUG 2010

DOI: 10.1002/9780470875780.ch5

Organelle-Specific Pharmaceutical Nanotechnology

Organelle-Specific Pharmaceutical Nanotechnology

How to Cite

Bricklebank, N. (2010) Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and Therapeutic Agents, in Organelle-Specific Pharmaceutical Nanotechnology (eds V. Weissig and G. G. M. D'Souza), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470875780.ch5

Editor Information

  1. 2

    Department of Pharmaceutical Sciences, Midwestern University College of Pharmacy, Glendale, Arizona, USA

  2. 3

    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA

Author Information

  1. Faculty of Health and Wellbeing, Biomedical Research Center, Sheffield Hallam University, Sheffield, United Kingdom

Publication History

  1. Published Online: 25 AUG 2010
  2. Published Print: 11 OCT 2010

ISBN Information

Print ISBN: 9780470631652

Online ISBN: 9780470875780



  • metal nanoparticle-based intracellular biosensor and therapeutic agent synthesis;
  • functionalized particle synthesis - through ligand exchange;
  • funtionalized metal nanoparticles by cells - and attractive carrier systems for transporting drugs, biomolecules


This chapter contains sections titled:

  • Introduction

  • Synthesis of Metal Nanoparticles

  • Synthesis of Functionalized Particles through Ligand Exchange

  • Nanoparticle – DNA Interactions

  • Functionalized Nanoparticles for Biological Detection

  • Metal Nanoparticles as Therapeutic Agents

  • Toxicology of Metal Nanoparticles

  • Conclusions and Future Prospects

  • References