11. Composite Approaches to Protein Tertiary Structure Prediction: A Case-Study by I-Tasser

  1. Huzefa Rangwala2 and
  2. George Karypis3
  1. Ambrish Roy,
  2. Sitao Wu and
  3. Yang Zhang

Published Online: 7 SEP 2010

DOI: 10.1002/9780470882207.ch11

Introduction to Protein Structure Prediction: Methods and Algorithms

Introduction to Protein Structure Prediction: Methods and Algorithms

How to Cite

Roy, A., Wu, S. and Zhang, Y. (2010) Composite Approaches to Protein Tertiary Structure Prediction: A Case-Study by I-Tasser, in Introduction to Protein Structure Prediction: Methods and Algorithms (eds H. Rangwala and G. Karypis), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470882207.ch11

Editor Information

  1. 2

    Department of Computer Science, George Mason University, Fairfax, VA 22030, USA

  2. 3

    Department of Computer Science, University of Minnesota Minneapolis, MN 55455, USA

Author Information

  1. Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA

Publication History

  1. Published Online: 7 SEP 2010
  2. Published Print: 12 NOV 2010

Book Series:

  1. Wiley Series on Bioinformatics: Computational Techniques and Engineering

Book Series Editors:

  1. Yi Pan and
  2. Albert Zomaya

ISBN Information

Print ISBN: 9780470470596

Online ISBN: 9780470882207

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Keywords:

  • composite approaches to protein tertiary structure prediction - TASSER, hierarchical protein structure modeling approach based on multiple threading alignments;
  • powerful sequence alignment algorithms - Basic Local Alignment Search Tool (BLAST), Position-Specific Iterative-BLAST (PSI-BLAST) and hidden Markov model (HMM) techniques;
  • extending reduced I-TASSER modeling to atomic representation - improving modeling accuracy at atomic level

Summary

This chapter contains sections titled:

  • Introduction

  • I-Tasser: A Composite Method for Protein Structure Prediction

  • AB Initio Prediction of I-Tasser on Small Proteins

  • Blind Test of I-Tasser in CASP Experiments

  • Concluding Remarks

  • References