31. Heterogeneity of Differential Expression in Cancer Studies: Algorithms and Methods

  1. Mourad Elloumi2 and
  2. Albert Y. Zomaya3
  1. Radha Krishna and
  2. Murthy Karuturi

Published Online: 23 DEC 2010

DOI: 10.1002/9780470892107.ch31

Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications

Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications

How to Cite

Krishna, R. and Karuturi, M. (2011) Heterogeneity of Differential Expression in Cancer Studies: Algorithms and Methods, in Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications (eds M. Elloumi and A. Y. Zomaya), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470892107.ch31

Editor Information

  1. 2

    Unit of Technologies of Information and Communication (UTIC) and University of Tunis-El Manar, Tunisia

  2. 3

    School of Information Technologies, The University of Sydney, Australia

Author Information

  1. Computational and Systems Biology, Genome Institute of Singapore

Publication History

  1. Published Online: 23 DEC 2010
  2. Published Print: 18 JAN 2011

ISBN Information

Print ISBN: 9780470505199

Online ISBN: 9780470892107

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Keywords:

  • heterogeneity of differential expression in cancer studies - algorithms and methods, microarray data measuring expression of M genes among N tissue (tumor or normal) samples;
  • differential variability of expression, gene deregulated in cancer - not demonstrating unidirectional change in its mRNA levels in tumor samples group;
  • gene interactome, as gene–gene correlation structure - from expression data under consideration, or other biological knowledge

Summary

This chapter contains sections titled:

  • Introduction

  • Notations

  • Differential Mean of Expression

  • Differential Variability of Expression

  • Differential Expression in Compendium of Tumors

  • Differential Expression by Chromosomal Aberrations: The Local Properties

  • Differential Expression in Gene Interactome

  • Differential Coexpression: Global MultiDimensional Interactome

  • Acknowledgments

  • References