10. Preclinical Candidate Nomination and Development

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Nils Bergenhem

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch10

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Bergenhem, N. (2011) Preclinical Candidate Nomination and Development, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch10

Author Information

  1. Vice President & CSO, CPEX Pharmaceuticals, Inc., 2 Holland Way, Exeter, NH, USA

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • preclinical candidate nomination and development - goal of preclinical development, generating data and documentation of drug candidate to complete IND application;
  • attrition rate of drug discovery and development candidates - key to strategic goals for preclinical candidate selection;
  • preclinical drug development, a process - data collected, terminating a compounds' development

Summary

This chapter contains sections titled:

  • Introduction

  • Investigational New Drug Application and Clinical Development

  • Strategic Goals for the Preclinical Development

  • Selection of Preclinical Development Candidate

  • CMC

  • Preclinical Studies

  • Conclusions

  • References