3. Absorption and Physicochemical Properties of the NCE

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Jon Selbo1 and
  2. Po-Chang Chiang2

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch3

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Selbo, J. and Chiang, P.-C. (2011) Absorption and Physicochemical Properties of the NCE, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch3

Author Information

  1. 1

    SSCI, A Division of Aptuit, West Lafayette, Indiana, USA

  2. 2

    Pfizer Inc., Chesterfield Parkway West, Chesterfield, Missouri, UK

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

SEARCH

Keywords:

  • absorption, and physicochemical properties of NCE;
  • ionizable compound solubility calculation - from its pH-solubility profile as given by Henderson–Hasselbalch equation;
  • pH solubility curve for a basic drug

Summary

This chapter contains sections titled:

  • Introduction

  • Physicochemical Properties

  • Stability

  • Dissolution and Solubility

  • Solid State

  • References