5. Pharmacokinetics for Medicinal Chemists

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Leonid (Leo) Kirkovsky and
  2. Anup Zutshi

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch5

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Kirkovsky, L. and Zutshi, A. (2011) Pharmacokinetics for Medicinal Chemists, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch5

Author Information

  1. Pfizer Inc., Chesterfield Parkway West, Chesterfield, Missouri, UK

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • pharmacokinetics for medicinal chemists;
  • PK data analysis - after multiple dose administrations;
  • stages of discovery process - and primary purposes of animal PK studies

Summary

This chapter contains sections titled:

  • Introduction

  • ADME

  • The Mathematics of Pharmacokinetics

  • Drug Administration and PK Observations

  • Human PK Projection

  • PK Practices

  • Engineering Molecules with Desired ADME Profile

  • 5.A Appendices

  • Acknowledgments

  • References