6. Cardiac Toxicity

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Ralf Kettenhofen and
  2. Silke Schwengberg

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch6

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Kettenhofen, R. and Schwengberg, S. (2011) Cardiac Toxicity, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch6

Author Information

  1. AXIOGENESIS AG, Nattermannallee, Cologne, Germany

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • cardiac toxicity and nonarrhythmic cardiac toxicity;
  • preclinical models for assessment - of ion channel-related cardiotoxicity;
  • pluripotent stem cell-derived cardiomyocytes - either from mouse or human origin, promising cellular models combining cell line advantages

Summary

This chapter contains sections titled:

  • Introduction

  • Ion Channel-Related Cardiac Toxicity

  • Nonarrhythmic Cardiac Toxicity

  • References