7. Genetic Toxicity: In Vitro Approaches for Medicinal Chemists

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Richard M. Walmsley1 and
  2. David Elder2

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch7

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Walmsley, R. M. and Elder, D. (2011) Genetic Toxicity: In Vitro Approaches for Medicinal Chemists, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch7

Author Information

  1. 1

    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

  2. 2

    GalaxoSmithKline Research and Development, Externalisation Group, PCD, Ware, United Kingdom

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • genetic toxicity, In vitro approaches for medicinal chemists - genotoxins, as agents causing genome damage;
  • hazards, and genome-damaging agent exposure - met by highly evolved and conserved cellular mechanisms for damage recognition;
  • genotoxicity assays for screening - regulatory genotoxicity assays, early profiling, contrasted with properties of discovery stage screening assays

Summary

This chapter contains sections titled:

  • Introduction

  • Limitations in the Regulatory In Vitro Genotoxicity Tests

  • Practical Issues for Genotoxicity Profiling

  • Computational Approaches to Genotoxicity Assessment: The In Silico Methods

  • Genotoxicity Assays for Screening

  • The “Omics”

  • Using Data from In Vitro Profiling: Confirmatory Tests, Follow-Up Tests, and the Link to Safety Assessment and In Vivo Models

  • What to Test, When, and How

  • Changes to Regulatory Guidelines Can Influence Screening Strategy

  • Summary

  • Acknowledgment

  • References