8. Hepatic Toxicity

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. Jinghai James Xu1 and
  2. Keith Hoffmaster2

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch8

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Xu, J. J. and Hoffmaster, K. (2011) Hepatic Toxicity, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch8

Author Information

  1. 1

    Merck Research Labs, West Point, Pennsylvania, UK

  2. 2

    Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, UK

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • hepatic toxicity;
  • reactive metabolites, formed by enzymes - involved in drug metabolism;
  • assays and test systems, measuring types of DILI - In vitro assay systems, predictivity and throughput for lead optimization programs of drug discovery process

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanisms of DILI

  • Assays and Test Systems to Measure Various Types of DILI

  • Medicinal Chemistry Strategies to Minimize DILI

  • Future Outlooks

  • Acknowledgment

  • References