9. In Vivo Toxicological Considerations

  1. Katya Tsaioun and
  2. Steven A. Kates
  1. John P. Devine Jr.

Published Online: 29 NOV 2010

DOI: 10.1002/9780470915110.ch9

ADMET for Medicinal Chemists: A Practical Guide

ADMET for Medicinal Chemists: A Practical Guide

How to Cite

Devine, J. P. (2011) In Vivo Toxicological Considerations, in ADMET for Medicinal Chemists: A Practical Guide (eds K. Tsaioun and S. A. Kates), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470915110.ch9

Author Information

  1. Basi Mount Vernon, Indiana, UK

Publication History

  1. Published Online: 29 NOV 2010
  2. Published Print: 10 JAN 2011

ISBN Information

Print ISBN: 9780470484074

Online ISBN: 9780470915110

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Keywords:

  • In vivo toxicological considerations - role of medicinal chemist, designing molecules with a therapeutic benefit;
  • route of administration (ROA) - path by which a drug, introduced into a biological test system;
  • goal, dose level selection in repeat-dose studies - a no-effect level at the lowest dose

Summary

This chapter contains sections titled:

  • Introduction

  • Route of Administration

  • Formulation Issues

  • Compound Requirements

  • Animal Models

  • IND-Supporting Toxicology Studies

  • Study Result Interpretation

  • Genetic Toxicology Studies

  • Conclusion

  • References