10. Developmental Trajectories of Autism and Environmental Exposures—What We Know and Where We Need to Go

  1. Cheng Wang and
  2. William Slikker Jr.
  1. Cindy P. Lawler1 and
  2. Alycia Halladay2

Published Online: 15 NOV 2010

DOI: 10.1002/9780470917060.ch10

Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms

Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms

How to Cite

Lawler, C. P. and Halladay, A. (2011) Developmental Trajectories of Autism and Environmental Exposures—What We Know and Where We Need to Go, in Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms (eds C. Wang and W. Slikker), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470917060.ch10

Editor Information

  1. National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR, USA

Author Information

  1. 1

    Cellular, Organ and Systems Pathobiology Branch Division of Extramural Research and Training National Institute of Environmental Health Sciences Keystone Building, Room 3022, 530 Davis Drive, Research Triangle Park, NC, USA

  2. 2

    Director of Research for Environmental Sciences, Autism Speaks, 2 Park Avenue, New York, NY, USA

Publication History

  1. Published Online: 15 NOV 2010
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9780470426722

Online ISBN: 9780470917060

SEARCH

Keywords:

  • autism and environmental exposure, and developmental trajectories - what we know and where we need to go;
  • DOHaD, credible new perspective - environmental exposures, counterweight to emphasis in ASD and other human diseases;
  • autism genetics, identifying gene–behavior relationships - complementary and parallel approaches

Summary

This chapter contains sections titled:

  • Introduction

  • Diagnosis of Autism

  • Early Developmental Trajectories of Autism

  • Use of High Risk Populations to Study Early Signs and Trajectories

  • Development of Screening Tools for Infants

  • Biomarkers of Autism

  • Autism Genetics

  • Epigenetics

  • Potential Exposures of Interest

  • Teratogens: Valproic Acid and Thalidomide

  • Psychosocial Stressors

  • Terbutaline

  • Pesticides

  • Mercury

  • Confronting the Universe of Exposures with Potential Relevance to Autism

  • The Path Forward

  • Conclusion

  • References