Structure and Mechanism of RND-Type Multidrug Efflux Pumps

  1. Eric J. Toone
  1. Hiroshi Nikaido

Published Online: 23 FEB 2011

DOI: 10.1002/9780470920541.ch1

Advances in Enzymology and Related Areas of Molecular Biology

Advances in Enzymology and Related Areas of Molecular Biology

How to Cite

Nikaido, H. (2011) Structure and Mechanism of RND-Type Multidrug Efflux Pumps, in Advances in Enzymology and Related Areas of Molecular Biology (ed E. J. Toone), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470920541.ch1

Editor Information

  1. Duke University, Durham, North Carolina, USA

Author Information

  1. Department of Molecular and Cell Biology, Barker Hall, University of California, Berkeley, CA 94720-3202, USA

Publication History

  1. Published Online: 23 FEB 2011
  2. Published Print: 11 APR 2011

ISBN Information

Print ISBN: 9780470638354

Online ISBN: 9780470920541

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Keywords:

  • structure and mechanism of RND-type multidrug efflux pumps;
  • structure of AcrB - determining structure of AcrB during drug export cycle;
  • drug efflux mechanisms - biochemical studies of conformational alterations

Summary

This chapter contains sections titled:

  • Introduction

  • Biochemical and Genetic Studies

  • Structure of AcrB

  • Mechanism of Drug Efflux

  • AcrAB-TolC and Drug Resistance

  • Coda

  • Acknowledgements

  • References