Efflux Pumps of the Resistance–Nodulation–Division Family: A Perspective of their Structure, Function, and Regulation in Gram-Negative Bacteria

  1. Eric J. Toone
  1. Mathew D. Routh1,
  2. Yaramah Zalucki2,
  3. Chih-Chia Su3,
  4. Feng Long1,
  5. Qijing Zhang4,
  6. William M. Shafer2,5 and
  7. Edward W. Yu6

Published Online: 23 FEB 2011

DOI: 10.1002/9780470920541.ch3

Advances in Enzymology and Related Areas of Molecular Biology

Advances in Enzymology and Related Areas of Molecular Biology

How to Cite

Routh, M. D., Zalucki, Y., Su, C.-C., Long, F., Zhang, Q., Shafer, W. M. and Yu, E. W. (2011) Efflux Pumps of the Resistance–Nodulation–Division Family: A Perspective of their Structure, Function, and Regulation in Gram-Negative Bacteria, in Advances in Enzymology and Related Areas of Molecular Biology (ed E. J. Toone), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470920541.ch3

Editor Information

  1. Duke University, Durham, North Carolina, USA

Author Information

  1. 1

    Molecular, Cellular and Developmental Biology Interdepartmental Graduate Program, Iowa State University, Ames, IA 50011, USA

  2. 2

    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA

  3. 3

    Department of Chemistry, Iowa State University, Ames, IA 50011, USA

  4. 4

    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA

  5. 5

    Laboratories of Microbial Pathogenesis, VA Medical Center, Decatur, GA 30033, USA

  6. 6

    Molecular, Cellular and Developmental Biology Interdepartmental Graduate Program, Department of Chemistry, Department of Physics and Astronomy, and Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA

Publication History

  1. Published Online: 23 FEB 2011
  2. Published Print: 11 APR 2011

ISBN Information

Print ISBN: 9780470638354

Online ISBN: 9780470920541

SEARCH

Keywords:

  • efflux pumps of resistance–nodulation–division family - structure, function and regulation in gram-negative bacteria;
  • efflux pumps of Neisseria gonorrhoeae - repertoire, and contributions to antimicrobial resistance;
  • RND multidrug efflux pump overexpression - and resistant phenotype in pathogenic organisms, for designing agents that block pump function

Summary

This chapter contains sections titled:

  • Introduction

  • Escherichia coli AcrAB-TolC Efflux System

  • Escherichia coli CusABC Efflux System

  • Campylobacter jejuni CmeABC Efflux System

  • Efflux Pumps of Neisseria gonorrhoeae: Repertoire and Contributions to Antimicrobial Resistance Resistance

  • Concluding Remarks

  • Acknowledgements

  • References