1. Introduction to Mass Spectrometry

  1. Birendra N. Pramanik5,
  2. Mike S. Lee6 and
  3. Guodong Chen7
  1. Scott A. Smith1,
  2. Ruth Waddell Smith1,2,
  3. Yu Xia3 and
  4. Zheng Ouyang4

Published Online: 12 JUL 2011

DOI: 10.1002/9780470921371.ch1

Characterization of Impurities and Degradants Using Mass Spectrometry

Characterization of Impurities and Degradants Using Mass Spectrometry

How to Cite

Smith, S. A., Smith, R. W., Xia, Y. and Ouyang, Z. (2011) Introduction to Mass Spectrometry, in Characterization of Impurities and Degradants Using Mass Spectrometry (eds B. N. Pramanik, M. S. Lee and G. Chen), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470921371.ch1

Editor Information

  1. 5

    Merck and Co., Kenilworth, NJ, USA

  2. 6

    Milestone Development Services, Newtown, PA, USA

  3. 7

    Bristol-Myers Squibb Company, Princeton, NJ, USA

Author Information

  1. 1

    Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA

  2. 2

    Forensic Science Program, School of Criminal Justice, Michigan State University, East Lansing, MI 48824, USA

  3. 3

    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

  4. 4

    Weldon School of Biomedical Engineering, Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA

Publication History

  1. Published Online: 12 JUL 2011
  2. Published Print: 16 MAY 2011

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications, and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, Newtown, PA, USA

ISBN Information

Print ISBN: 9780470386187

Online ISBN: 9780470921371

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Keywords:

  • mass spectrometry, roots in atomic physics - fast-atom bombardment (FAB) and liquid secondary ionization MS (LSIMS), promising in biomolecule analysis;
  • tandem mass spectrometry, or tandem MS - using multiple stages of ion manipulations, m/z isolation and fragmentation;
  • separation techniques coupled to mass spectrometry - gas chromatography–mass spectrometry

Summary

This chapter contains sections titled:

  • History

  • Ionization Methods

  • Mass Spectrometer Types

  • Tandem Mass Spectrometry

  • Separation Techniques Coupled to Mass Spectrometry

  • Prospects for Mass Spectrometry

  • References