4. Orbitrap High-Resolution Applications

  1. Birendra N. Pramanik2,
  2. Mike S. Lee3 and
  3. Guodong Chen4
  1. Robert J. Strife

Published Online: 12 JUL 2011

DOI: 10.1002/9780470921371.ch4

Characterization of Impurities and Degradants Using Mass Spectrometry

Characterization of Impurities and Degradants Using Mass Spectrometry

How to Cite

Strife, R. J. (2011) Orbitrap High-Resolution Applications, in Characterization of Impurities and Degradants Using Mass Spectrometry (eds B. N. Pramanik, M. S. Lee and G. Chen), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470921371.ch4

Editor Information

  1. 2

    Merck and Co., Kenilworth, NJ, USA

  2. 3

    Milestone Development Services, Newtown, PA, USA

  3. 4

    Bristol-Myers Squibb Company, Princeton, NJ, USA

Author Information

  1. Procter & Gamble, 8700 Mason-Montgomery Road, Mason, OH 45040, USA

Publication History

  1. Published Online: 12 JUL 2011
  2. Published Print: 16 MAY 2011

Book Series:

  1. Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications, and Methods

Book Series Editors:

  1. Mike S. Lee

Series Editor Information

  1. Milestone Development Services, Newtown, PA, USA

ISBN Information

Print ISBN: 9780470386187

Online ISBN: 9780470921371

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Keywords:

  • Orbitrap high-resolution applications, “Fourier transform” device or Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS);
  • the Orbitrap success, as a mass spectrometer - in Orbitrap performance, range of applications;
  • substructure determination, and Orbitrap tandem mass spectrometry (MSn) - fragmenting ions and building substructural hypotheses

Summary

This chapter contains sections titled:

  • Historical Anecdote

  • General Description of Orbitrap Operating Principles

  • The Orbitrap is a “Fourier Transform” Device

  • Performing Experiments in Trapping Devices

  • Determining Elemental Compositions of “Unknowns” Using an Orbitrap

  • Orbitrap Figures of Merit in Mass Measurement

  • HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space

  • Determination of Trace Contaminant Compositions by Simple Screening HPLC-MS and Infusion Orbitrap MS

  • Determining Substructures: Orbitrap Tandem Mass Spectrometry (MSn)

  • Multianalyzer (Hybridized) System: The Linear Ion Trap/Orbitrap for MS/MS and Higher-Order MSn, n > 2

  • Mass Mapping to Discover Impurities

  • The Current Practice of Orbitrap Mass Spectrometry

  • Conclusion

  • References