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Structure and Function of Cytochrome P450 Enzymes

Part II. Enzyme Systems Involved in Drug Metabolism and Interactions in Animals and Humans

  1. Paul R. Ortiz de Montellano

Published Online: 31 JAN 2012

DOI: 10.1002/9780470921920.edm006

Encyclopedia of Drug Metabolism and Interactions

Encyclopedia of Drug Metabolism and Interactions

How to Cite

Ortiz de Montellano, P. R. 2012. Structure and Function of Cytochrome P450 Enzymes. Encyclopedia of Drug Metabolism and Interactions. II:1–19.

Author Information

  1. University of California, Department of Pharmaceutical Chemistry, San Francisco, CA, USA

Publication History

  1. Published Online: 31 JAN 2012

Abstract

This chapter summarizes the distribution and function of the human cytochrome P450 enzymes, including their relative abundance and polymorphisms, general spectroscopic properties, and structures. The universal catalytic cycle of cytochrome P450 enzymes, including the requisite electron-donor partners, is also described.

Keywords:

  • cytochrome P450;
  • P450 polymorphisms;
  • P450 catalytic cycle;
  • P450 structure;
  • P450 ligand binding;
  • P450 spectra