12. Strategic Approaches to the Chromatographic Analysis of Genotoxic Impurities

  1. Andrew Teasdale
  1. Frank David,
  2. Karine Jacq,
  3. Gerd Vanhoenacker and
  4. Pat Sandra

Published Online: 3 JAN 2011

DOI: 10.1002/9780470929377.ch12

Genotoxic Impurities

Genotoxic Impurities

How to Cite

David, F., Jacq, K., Vanhoenacker, G. and Sandra, P. (2011) Strategic Approaches to the Chromatographic Analysis of Genotoxic Impurities, in Genotoxic Impurities (ed A. Teasdale), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470929377.ch12

Editor Information

  1. AstraZeneca, Leicester, United Kingdom

Author Information

  1. Research Institute for Chromatography, Kortrijik, Belgium

Publication History

  1. Published Online: 3 JAN 2011
  2. Published Print: 14 FEB 2011

ISBN Information

Print ISBN: 9780470499191

Online ISBN: 9780470929377

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Keywords:

  • strategic approaches to chromatographic analysis - of genotoxic impurities;
  • S-and N-Mustards - Mustards are β-halogenated dialkylsulfides (S-mustards) or β-halogenated amines (N-mustards);
  • analysis of epoxides, the same approach - for the Michael reaction acceptors

Summary

This chapter contains sections titled:

  • Introduction

  • Instrumentation

  • Alkyl Halides and Aryl Halides

  • Sulfonates

  • S- and N-Mustards

  • Michael Reaction Acceptors

  • Epoxides

  • Haloalcohols

  • Aziridines

  • Arylamines and Aminopyridines

  • Hydrazines

  • Aldehydes and Ketones

  • Conclusions

  • Acknowledgments

  • References