13. Analysis of Genotoxic Impurities by Nuclear Magnetic Resonance Spectroscopy

  1. Andrew Teasdale
  1. Andrew Phillips

Published Online: 3 JAN 2011

DOI: 10.1002/9780470929377.ch13

Genotoxic Impurities

Genotoxic Impurities

How to Cite

Phillips, A. (2011) Analysis of Genotoxic Impurities by Nuclear Magnetic Resonance Spectroscopy, in Genotoxic Impurities (ed A. Teasdale), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470929377.ch13

Editor Information

  1. AstraZeneca, Leicester, United Kingdom

Author Information

  1. AstraZeneca, Cheshire, United Kingdom

Publication History

  1. Published Online: 3 JAN 2011
  2. Published Print: 14 FEB 2011

ISBN Information

Print ISBN: 9780470499191

Online ISBN: 9780470929377

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Keywords:

  • analysis of genotoxic impurities - by nuclear magnetic resonance spectroscopy;
  • sensitivity of given experiment - what is done to maximize sensitivity;
  • NMR, inherently insensitive technique - not the natural choice for trace analysis

Summary

This chapter contains sections titled:

  • Introduction to NMR

  • Why is NMR an Insensitive Technique?

  • How could NMR be Used for Trace Analysis?

  • What can be Done to Maximize Sensitivity?

  • Case Studies

  • Conclusion

  • References