2. Development of the Threshold of Toxicological Concern Concept and its Relationship to Duration of Exposure

  1. Andrew Teasdale
  1. Alessandro Brigo and
  2. Lutz Müller

Published Online: 3 JAN 2011

DOI: 10.1002/9780470929377.ch2

Genotoxic Impurities

Genotoxic Impurities

How to Cite

Brigo, A. and Müller, L. (2011) Development of the Threshold of Toxicological Concern Concept and its Relationship to Duration of Exposure, in Genotoxic Impurities (ed A. Teasdale), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470929377.ch2

Editor Information

  1. AstraZeneca, Leicester, United Kingdom

Author Information

  1. F. Hoffman-La Roche AG, Basel, Switzerland

Publication History

  1. Published Online: 3 JAN 2011
  2. Published Print: 14 FEB 2011

ISBN Information

Print ISBN: 9780470499191

Online ISBN: 9780470929377

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Keywords:

  • threshold of toxicological concern concept development - its relationship to exposure duration;
  • TTC principle, developed from toxicity databases;
  • group chemicals and linear extrapolation at low dose

Summary

This chapter contains sections titled:

  • History and Development of Threshold of Toxicological Concern (TTC)

  • Current Applications of the TTC Concept

  • Group Chemicals and Linear Extrapolation at Low Dose

  • Cumulation Versus Addition

  • Conclusions and Perspectives

  • References