4. Use of Structure Activity Relationship (SAR) Evaluation as a Critical Tool in the Evaluation of the Genotoxic Potential of Impurities

  1. Andrew Teasdale
  1. Susanne Glowienke1 and
  2. Catrin Hasselgren2

Published Online: 3 JAN 2011

DOI: 10.1002/9780470929377.ch4

Genotoxic Impurities

Genotoxic Impurities

How to Cite

Glowienke, S. and Hasselgren, C. (2011) Use of Structure Activity Relationship (SAR) Evaluation as a Critical Tool in the Evaluation of the Genotoxic Potential of Impurities, in Genotoxic Impurities (ed A. Teasdale), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470929377.ch4

Editor Information

  1. AstraZeneca, Leicester, United Kingdom

Author Information

  1. 1

    Novartis, Basel, Switzerland

  2. 2

    AstraZeneca, Mölndal, Sweden

Publication History

  1. Published Online: 3 JAN 2011
  2. Published Print: 14 FEB 2011

ISBN Information

Print ISBN: 9780470499191

Online ISBN: 9780470929377

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Keywords:

  • use of structure activity relationship (SAR) evaluation - a critical tool in evaluation of genotoxic potential of impurities;
  • ICSAS method for structural alerts (modified);
  • TOPKAT (Toxicity Prediction by Komputer Assisted Technology) - TOPKAT using Kier & Hall electrotopological states (E-states), and shape, symmetry, MW, and logP as descriptors

Summary

This chapter contains sections titled:

  • Introduction

  • Methodology

  • Validation

  • Conclusion

  • References