7. Genotoxic Thresholds

  1. Andrew Teasdale
  1. Gareth J. S. Jenkins,
  2. George E. Johnson,
  3. James M. Parry and
  4. Shareen H. Doak

Published Online: 3 JAN 2011

DOI: 10.1002/9780470929377.ch7

Genotoxic Impurities

Genotoxic Impurities

How to Cite

Jenkins, G. J. S., Johnson, G. E., Parry, J. M. and Doak, S. H. (2011) Genotoxic Thresholds, in Genotoxic Impurities (ed A. Teasdale), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470929377.ch7

Editor Information

  1. AstraZeneca, Leicester, United Kingdom

Author Information

  1. Swansea University, Wales, United Kingdom

Publication History

  1. Published Online: 3 JAN 2011
  2. Published Print: 14 FEB 2011

ISBN Information

Print ISBN: 9780470499191

Online ISBN: 9780470929377



  • risk perspective - posed by genotoxic impurities, and genotoxic thresholds;
  • indirect-acting genotoxins, not damaging DNA directly - interfering with DNA replication, transcription or repair processes;
  • genotoxic thresholds, existing - biological basis for thresholds, involving multiple cellular and extracellular mechanisms


This chapter contains sections titled:

  • Introduction to Genotoxic Dose Responses

  • Mechanisms Behind Thresholds

  • Conclusions

  • Acknowledgments

  • References