1. Gene Discovery: From Positional Cloning to Genomic Cloning

  1. Weikuan Gu2 and
  2. Yongjun Wang3
  1. Weikuan Gu2 and
  2. Daniel Goldowitz1

Published Online: 10 FEB 2012

DOI: 10.1002/9780470933947.ch1

Gene Discovery for Disease Models

Gene Discovery for Disease Models

How to Cite

Gu, W. and Goldowitz, D. (2011) Gene Discovery: From Positional Cloning to Genomic Cloning, in Gene Discovery for Disease Models (eds W. Gu and Y. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470933947.ch1

Editor Information

  1. 2

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

  2. 3

    Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Author Information

  1. 1

    Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

  2. 2

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

Publication History

  1. Published Online: 10 FEB 2012
  2. Published Print: 21 MAR 2011

ISBN Information

Print ISBN: 9780470499467

Online ISBN: 9780470933947

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Keywords:

  • gene discovery, positional to genomic cloning - new gene functions, mutated gene identification for disease in humans and other species;
  • gene discovery in post-genome era - highly integrative, based on genome resource and biotechnology availability;
  • next stage of gene discovery - high-throughput technology and bioinformatic tool development

Summary

This chapter contains sections titled:

  • Concept of Classic Positional Cloning

  • Concept of Gene Discovery in the Post-Genome Era

  • Strategies for Gene Discovery in the Post-Genome Era

  • Future Direction

  • References