16. Confirmation of a Mutation by MicroRNA

  1. Weikuan Gu1 and
  2. Yongjun Wang2
  1. Hongwei Zheng and
  2. Yongjun Wang

Published Online: 10 FEB 2012

DOI: 10.1002/9780470933947.ch16

Gene Discovery for Disease Models

Gene Discovery for Disease Models

How to Cite

Zheng, H. and Wang, Y. (2011) Confirmation of a Mutation by MicroRNA, in Gene Discovery for Disease Models (eds W. Gu and Y. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470933947.ch16

Editor Information

  1. 1

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

  2. 2

    Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Author Information

  1. Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Publication History

  1. Published Online: 10 FEB 2012
  2. Published Print: 21 MAR 2011

ISBN Information

Print ISBN: 9780470499467

Online ISBN: 9780470933947

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Keywords:

  • confirmation of a mutation by micro RNA - and biogenesis of miRNAs;
  • experiment using miRNA - confirming gene mutation function;
  • polymorphism/mutation in miRNA binding sites (poly-miRTS) - disease-target prediction programs defining potential miRNA targets

Summary

This chapter contains sections titled:

  • Basic Concept of MicroRNA and Relevance to Gene Function

  • Designing an Experiment Using MiRNA to Confirm Gene Mutation Function

  • Procedure of Confirmation of a Gene Mutation by MiRNA

  • Limitations and Troubleshooting

  • References