17. Confirmation of Gene Function Using Translational Approaches

  1. Weikuan Gu2 and
  2. Yongjun Wang3
  1. Caroline J. Zeiss

Published Online: 10 FEB 2012

DOI: 10.1002/9780470933947.ch17

Gene Discovery for Disease Models

Gene Discovery for Disease Models

How to Cite

Zeiss, C. J. (2011) Confirmation of Gene Function Using Translational Approaches, in Gene Discovery for Disease Models (eds W. Gu and Y. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470933947.ch17

Editor Information

  1. 2

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

  2. 3

    Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Author Information

  1. Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA

Publication History

  1. Published Online: 10 FEB 2012
  2. Published Print: 21 MAR 2011

ISBN Information

Print ISBN: 9780470499467

Online ISBN: 9780470933947

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Keywords:

  • confirmation of gene function - using translational approaches;
  • gene-driven or reverse genetics approach to mouse research - mutation in genes, and phenotype in mutant progeny;
  • forward genetics approach - genetic lesions, observation of a phenotype in progeny phenotype

Summary

This chapter contains sections titled:

  • Introduction

  • Sources of Phenotypic Variability in Genetically Altered Mice

  • Gene-Driven or Reverse Genetics Approach to Mouse Research

  • Phenotype-Driven or Forward Genetics Approach to Mouse Research

  • Information Resources

  • Questions and Answers

  • References