3. DNA Methylation in the Pathogenesis of Autoimmunity

  1. Weikuan Gu4 and
  2. Yongjun Wang5
  1. Xueqing Xu1,
  2. Ping Yang2,
  3. Zhang Shu2,
  4. Yun Bai1 and
  5. Cong-Yi Wang2,3

Published Online: 10 FEB 2012

DOI: 10.1002/9780470933947.ch3

Gene Discovery for Disease Models

Gene Discovery for Disease Models

How to Cite

Xu, X., Yang, P., Shu, Z., Bai, Y. and Wang, C.-Y. (2011) DNA Methylation in the Pathogenesis of Autoimmunity, in Gene Discovery for Disease Models (eds W. Gu and Y. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470933947.ch3

Editor Information

  1. 4

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

  2. 5

    Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Author Information

  1. 1

    Department of Medical Genetics, Third Military Medical University, Chongqing, China

  2. 2

    The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

  3. 3

    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USA

Publication History

  1. Published Online: 10 FEB 2012
  2. Published Print: 21 MAR 2011

ISBN Information

Print ISBN: 9780470499467

Online ISBN: 9780470933947



  • DNA methylation, in autoimmunity pathogenesis - type of post-synthesis modification after every cycle of DNA replication;
  • DNA methylation implication in autoimmune diseases - initiating heritable patterns of gene expression;
  • DNA methylome changes, and interactions between cis-acting elements - and protein factors, role in gene regulation


This chapter contains sections titled:

  • Introduction

  • General Information for DNA Methylation in Mammals

  • DNA Methyltransferases and Methyl-CpG-Binding Domain (MBD) Proteins

  • DNA Methylation in T and B Cell Development

  • The Implication of DNA Methylation in Autoimmune Diseases

  • Common Technological Approaches for Assay of DNA Methylation

  • Summary

  • Acknowledgments

  • References