5. Missing Dimension: Protein Turnover Rate Measurement in Gene Discovery

  1. Weikuan Gu2 and
  2. Yongjun Wang3
  1. Gary Guishan Xiao

Published Online: 10 FEB 2012

DOI: 10.1002/9780470933947.ch5

Gene Discovery for Disease Models

Gene Discovery for Disease Models

How to Cite

Xiao, G. G. (2011) Missing Dimension: Protein Turnover Rate Measurement in Gene Discovery, in Gene Discovery for Disease Models (eds W. Gu and Y. Wang), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470933947.ch5

Editor Information

  1. 2

    Department of Orthopedic Surgery—Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA

  2. 3

    Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Author Information

  1. Hospital Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

Publication History

  1. Published Online: 10 FEB 2012
  2. Published Print: 21 MAR 2011

ISBN Information

Print ISBN: 9780470499467

Online ISBN: 9780470933947

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Keywords:

  • protein turnover, a significant missing dimension - in gene function and discovery;
  • determination of rate of turnover of specific proteins - dynamics of protein turnover, key to understanding protein expression regulation in cells;
  • newly developed technology, and protein synthesis rate determination - labeling of amino acids with deuterium

Summary

This chapter contains sections titled:

  • Protein Turnover as Significant Missing Dimension in Gene Function and Discovery

  • Determination of the Rate of Turnover of Specific Proteins

  • Future Direction

  • Questions and Answers

  • Acknowledgments

  • References