11. Platelet Functional Genomics

  1. Ángel García5 and
  2. Yotis A. Senis6
  1. Isabelle I. Salles1,
  2. Marie N. O'Connor2,
  3. Daphne C. Thijssen-Timmer3,
  4. Katleen Broos4 and
  5. Hans Deckmyn4

Published Online: 12 JUL 2011

DOI: 10.1002/9780470940297.ch11

Platelet Proteomics: Principles, Analysis, and Applications

Platelet Proteomics: Principles, Analysis, and Applications

How to Cite

Salles, I. I., O'Connor, M. N., Thijssen-Timmer, D. C., Broos, K. and Deckmyn, H. (2011) Platelet Functional Genomics, in Platelet Proteomics: Principles, Analysis, and Applications (eds Á. García and Y. A. Senis), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470940297.ch11

Editor Information

  1. 5

    Department of Pharmacology, Facultade de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

  2. 6

    Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

Author Information

  1. 1

    Department of Haematology, Imperial College London, London, United Kingdom

  2. 2

    MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom

  3. 3

    Department of Experimental Immunohaematology, Sanquin Research, and Landsteiner Laboratory, AMC, University of Amsterdam, Amsterdam, The Netherlands

  4. 4

    Laboratory for Thrombosis Research, KU Leuven Campus Kortrijk, Kortrijk, Belgium

Publication History

  1. Published Online: 12 JUL 2011
  2. Published Print: 9 MAY 2011

Book Series:

  1. Wiley-Interscience Series in Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio7 and
  2. Nico M. M. Nibbering8

Series Editor Information

  1. 7

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 8

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470463376

Online ISBN: 9780470940297



  • platelet functional genomics, functional roles - of candidate genes and proteins, and megakaryocytes;
  • genetic manipulation of mammalian megakaryocytes - MK and platelets, in vitro and in vivo approaches;
  • promise, of human platelet production in experimental animals - entailing new perspectives


This chapter contains sections titled:

  • Introduction

  • Nonmammalian Vertebrate Model Systems

  • Genetic Manipulation of Mammalian Megakaryocytes

  • Concluding Remarks

  • References