12. Systems Biology to Study Platelet-Related Bleeding Disorders

  1. Ángel García3 and
  2. Yotis A. Senis4
  1. Jan-Willem N. Akkerman1 and
  2. Bernard De Bono2

Published Online: 12 JUL 2011

DOI: 10.1002/9780470940297.ch12

Platelet Proteomics: Principles, Analysis, and Applications

Platelet Proteomics: Principles, Analysis, and Applications

How to Cite

Akkerman, J.-W. N. and De Bono, B. (2011) Systems Biology to Study Platelet-Related Bleeding Disorders, in Platelet Proteomics: Principles, Analysis, and Applications (eds Á. García and Y. A. Senis), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470940297.ch12

Editor Information

  1. 3

    Department of Pharmacology, Facultade de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

  2. 4

    Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

Author Information

  1. 1

    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

  2. 2

    European Bioinformatics Institute, EMBL Cambridge, United Kingdom

Publication History

  1. Published Online: 12 JUL 2011
  2. Published Print: 9 MAY 2011

Book Series:

  1. Wiley-Interscience Series in Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio5 and
  2. Nico M. M. Nibbering6

Series Editor Information

  1. 5

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 6

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470463376

Online ISBN: 9780470940297



  • systems biology, for studying platelet-related bleeding disorders - crucial platform for knowledge accumulation of signaling pathways;
  • platelet activation, through leucine-rich repeat family, glycoprotein Ibα - and signal induction;
  • connectivity schemes, platelet signaling machinery - complexity of activating and inhibitory pathways


This chapter contains sections titled:

  • Introduction: Initiation, Inhibition, and Termination of Platelet Functions

  • Platelet Activation through Seven-Transmembrane Receptors

  • Platelet Activation through the Leucine-Rich Repeat Family: Glycoprotein Ibα

  • Platelet Activation through Integrins

  • Signaling by Receptors of the Immunoglobulin Family

  • Tyr-Kinase Receptors

  • Platelet Proteomics and Systems Biology

  • Increased Bleeding Tendency

  • Concluding Remarks

  • Acknowledgment

  • Abbreviations

  • References