2. Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research

  1. Ángel García2 and
  2. Yotis A. Senis3
  1. Julia Maria Burkhart and
  2. Albert Sickmann

Published Online: 12 JUL 2011

DOI: 10.1002/9780470940297.ch2

Platelet Proteomics: Principles, Analysis, and Applications

Platelet Proteomics: Principles, Analysis, and Applications

How to Cite

Maria Burkhart, J. and Sickmann, A. (2011) Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research, in Platelet Proteomics: Principles, Analysis, and Applications (eds Á. García and Y. A. Senis), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470940297.ch2

Editor Information

  1. 2

    Department of Pharmacology, Facultade de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

  2. 3

    Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

Author Information

  1. Leibniz Institut für Analytische, Wissenschaften ISAS e.V., Dortmund, Germany

Publication History

  1. Published Online: 12 JUL 2011
  2. Published Print: 9 MAY 2011

Book Series:

  1. Wiley-Interscience Series in Mass Spectrometry

Book Series Editors:

  1. Dominic M. Desiderio4 and
  2. Nico M. M. Nibbering5

Series Editor Information

  1. 4

    Departments of Neurology and Biochemistry, University of Tennessee Health Science Center, USA

  2. 5

    Vrije Universiteit Amsterdam, The Netherlands

ISBN Information

Print ISBN: 9780470463376

Online ISBN: 9780470940297

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Keywords:

  • mass-spectrometry-based proteomics - posttranslational modification (PTMs) analysis, platelet research tools, protein pattern analysis;
  • absolute quantification, set of analytes - in sample, and absolute quantification (AQUA) strategy;
  • proteomic analyses of platelet proteome - novel insights, functional components of platelets

Summary

This chapter contains sections titled:

  • Introduction: Multidimensional Analysis of Complex Protein Samples

  • Global Analysis of the Platelet Proteome

  • Analysis of Subcellular Components

  • Posttranslational Modifications

  • Quantification Using Mass Spectrometry

  • Concluding Remarks

  • Acknowledgment

  • References