5. Animal, In Vitro, and Cell Culture Models to Study the Role of Dietary Fibers in the Gastrointestinal Tract of Humans

  1. Teri M. Paeschke2 and
  2. William R. Aimutis3
  1. Trevor A. Faber and
  2. George C. Fahey Jr.

Published Online: 16 MAR 2011

DOI: 10.1002/9780470958186.ch5

Nondigestible Carbohydrates and Digestive Health

Nondigestible Carbohydrates and Digestive Health

How to Cite

Faber, T. A. and Fahey, G. C. (2010) Animal, In Vitro, and Cell Culture Models to Study the Role of Dietary Fibers in the Gastrointestinal Tract of Humans, in Nondigestible Carbohydrates and Digestive Health (eds T. M. Paeschke and W. R. Aimutis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470958186.ch5

Editor Information

  1. 2

    Des Plaines, IL, USA

  2. 3

    Cargill, Inc., Wayzata, MN, USA

Author Information

  1. Department of Animal Sciences, University of Illinois, Urbana, IL, USA

Publication History

  1. Published Online: 16 MAR 2011
  2. Published Print: 12 NOV 2010

Book Series:

  1. IFT Press

ISBN Information

Print ISBN: 9780813817620

Online ISBN: 9780470958186

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Keywords:

  • animal, in vitro and cell culture models - dietary fiber role in gastrointestinal tract of humans;
  • beneficial physiological roles of plant fiber - in human diet, presently undisputed;
  • human subjects, gold standard - in substrate evaluation;
  • host–microbiota–substrate interaction - key determinant of fermentable ingredient efficacy;
  • animal evaluations of test substrates - cost-effective method to prescreen efficacy of substrate before human trials;
  • in vitro systems, screening test substrates - for hydrolytic and/or fermentative digestion capacity and kinetics;
  • hydrolytic and fermentative digestion systems;
  • simulated human intestinal microbial ecosystem (SHIME) - chemostatic system, evaluating complete digestive process;
  • fermentative in vitro systems - in vitro systems, simulating entire gastrointestinal tract;
  • EnteroMix® Colon Simulator - semicontinuous device of four vessels connected consecutively

Summary

This chapter contains sections titled:

  • Introduction

  • Animal Models

  • Rodent

  • Pig

  • Dog

  • In Vitro Systems

  • Hydrolytic and Fermentative Digestion Systems

  • Fermentative In Vitro Systems

  • Method Comparison

  • Cell Culture Models

  • Conclusion

  • References