Chapter 2. Water Mobility in Solid Pharmaceuticals as Determined by Nuclear Magnetic Resonance, Isothermal Sorption, and Dielectric Relaxation Measurements

  1. Dr. David S. Reid President2,
  2. Dr. Tanaboon Sajjaanantakul3,
  3. Dr. Peter J. Lillford4 and
  4. Dr. Sanguansri Charoenrein5
  1. S. Yoshioka and
  2. Y. Aso

Published Online: 14 MAY 2010

DOI: 10.1002/9780470958193.ch2

Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10

Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10

How to Cite

Yoshioka, S. and Aso, Y. (2010) Water Mobility in Solid Pharmaceuticals as Determined by Nuclear Magnetic Resonance, Isothermal Sorption, and Dielectric Relaxation Measurements, in Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10 (eds D. S. Reid, T. Sajjaanantakul, P. J. Lillford and S. Charoenrein), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470958193.ch2

Editor Information

  1. 2

    Department of Food Science and Technology, University of California, Davis, California, USA

  2. 3

    Kasetsart University, Thailand

  3. 4

    Centre for Formulation Engineering, Chemical Engineering, University of Birmingham, Birmingham, UK

  4. 5

    Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand

Author Information

  1. National Institute of Health Sciences, Tokyo, Japan

Publication History

  1. Published Online: 14 MAY 2010
  2. Published Print: 11 JUL 2010

ISBN Information

Print ISBN: 9780813812731

Online ISBN: 9780470958193

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Keywords:

  • water mobility - solid pharmaceuticals;
  • nuclear magnetic resonance, dielectric relaxation spectroscopy, differential scanning calorimetry, water-sorption isotherm data - molecular mobilities;
  • NMR - determining molecular mobility of water;
  • onset temperature - comparison of evaporation among API hydrates;
  • onset temperature - depending on heating rate, shapes of pan and lid, surface area of sample, flow rate;
  • hydration water - evaporating at lower temperatures;
  • water molecules - wide-ranging molecular mobilities;
  • pharmaceutical excipients - exhibiting water-sorption behaviors

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Apparent Correlations Between the Stability of Solid APIs and the Molecular Mobility of Water

  • Molecular Mobility of Water in API Hydrates

  • Molecular Mobility of Water Coexisting with Various Pharmaceutical Excipients

  • Concluding Remarks

  • References